Product Type
Fc Silent Antibody
Description
Anti-Human NGF-Fc silent antibody is a Human monoclonal antibody targeting the NGF. And it is intended for the research of Pain; osteoarthritis.
Research Area
Cell Biology, Immunology
Antigen Distribution
Broad expression in ovary (RPKM 1.3), heart (RPKM 0.5) and 18 other tissues
Disease
Pain; osteoarthritis
Size
100 ug
Immunogen
Recombinant Human NGF protein
Species
Human
Clonality
Monoclonal
Conjugation
Unconjugated
Source
Recombinant
Buffer
PBS, pH 7.4
Application
Funcs, In vivo assay
Application Notes
The use of diluent depends on the detection system used. It is recommended that users test reagents and determine their own optimal dilution.
Handling Advice
This product is for research use only. It is not intended for use in therapeutic or diagnostic procedures for humans or animals.
Storage Instructions
Product should be stored at -80°C. Repeated freeze and thaw cycles will cause loss of activity. Use product within 24 hours after thawing and keep on ice. Remainder amounts should be aliquoted and immediately re-freezed for future use. Aliquots should never be thawed more than once. Under recommended storage conditions, product is stable for at least one year.
Official Name
Beta-nerve growth factor
Full Name
Beta-nerve growth factor
Background
Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival. The immature NGF precursor (proNGF) functions as ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone collapse. In contrast to mature NGF, the precursor form (proNGF) promotes neuronal apoptosis (in vitro) (By similarity).
Alternative Names
Beta-nerve growth factor
Gene ID
4803
Uniprot ID
P01138
