Product Type
Fc Silent Antibody
Description
Anti-Human IL-12/IL-23 p40-Fc silent antibody is derived from clone #955, which is a Human monoclonal antibody targeting the IL-12/IL-23 p40. And it is intended for the research of Rheumatoid arthritis, inflammatory bowel disease, and multiple sclerosis.
Research Area
Cell Biology, Immunology
Antigen Distribution
IL-12 is produced by dendritic cells, macrophages, neutrophils, and human B-lymphoblastoid cells. IL-23 is mainly secreted by activated dendritic cells, macrophages or monocytes.
Disease
Rheumatoid arthritis, inflammatory bowel disease, and multiple sclerosis
Size
100 ug
Immunogen
Recombinant Human IL-12/IL-23 p40 protein
Species
Human
Clonality
Monoclonal
Clone Number
#955
Conjugation
Unconjugated
Source
Recombinant
Buffer
PBS, pH 7.4
Application
Block, ELISA, FuNeutcS, FC, IF, IP, Neut, WB
Application Notes
The use of diluent depends on the detection system used. It is recommended that users test reagents and determine their own optimal dilution.
Handling Advice
This product is for research use only. It is not intended for use in therapeutic or diagnostic procedures for humans or animals.
Storage Instructions
Product should be stored at -80°C. Repeated freeze and thaw cycles will cause loss of activity. Use product within 24 hours after thawing and keep on ice. Remainder amounts should be aliquoted and immediately re-freezed for future use. Aliquots should never be thawed more than once. Under recommended storage conditions, product is stable for at least one year.
Official Name
Interleukin-12 subunit beta
Full Name
Interleukin-12 subunit beta
Background
IL-12 associates with IL-23α to form the heterodimeric cytokine IL-23. IL-23 is associated with various autoimmune inflammatory diseases, and is particularly highly expressed in psoriasis skin lesions. In addition, IL-23 is suspected to play a role in tumorigenesis. Briakinumab binds to and neutralizes human IL-12 and IL-23 (via their shared p40 subunit) and is being investigated for the treatment of rheumatoid arthritis, inflammatory bowel disease, and multiple sclerosis.
Alternative Names
IL-12p40; Interleukin 12; Interleukin 23; IL12; IL23; IL-12; IL-23
Gene ID
3593
Uniprot ID
P29460
