Product Type
Fc Silent Antibody
Description
Anti-Human HER-2/neu-Fc silent antibody is derived from clone 4D5-8, which is a Human monoclonal antibody targeting the HER-2/neu. And it is intended for the research of Breast cancer, stomach cancer.
Research Area
Cell Biology, Immunology
Antigen Distribution
Ubiquitous expression with highest expression levels found in the kidney, skin, esophagus, and small intestine.
Disease
Breast cancer, stomach cancer
Immunogen
Recombinant Human HER-2/neu protein
Application
ELISA, FC, IHC
Application Notes
The use of diluent depends on the detection system used. It is recommended that users test reagents and determine their own optimal dilution.
Handling Advice
This product is for research use only. It is not intended for use in therapeutic or diagnostic procedures for humans or animals.
Storage Instructions
Product should be stored at -80°C. Repeated freeze and thaw cycles will cause loss of activity. Use product within 24 hours after thawing and keep on ice. Remainder amounts should be aliquoted and immediately re-freezed for future use. Aliquots should never be thawed more than once. Under recommended storage conditions, product is stable for at least one year.
Official Name
Receptor tyrosine-protein kinase erbB-2
Full Name
Receptor tyrosine-protein kinase erbB-2
Background
HER2, a transmembrane glycoprotein that contains an extracellular domain and intracellular tyrosine kinase activity. When it is functioning normally, the HER2 pathway supports cell growth and division. On the other hand, the over expression of HER2 propels cell growth beyond its typical range. This overexpression is associated with some cancers, namely breast and stomach, in which the HER2 protein can be expressed up to 100 times more than in typical cells.
Alternative Names
NEU; NGL; HER2; TKR1; CD340; HER-2; MLN 19; HER-2/neu
