Product Type
Antibody
Description
The monoclonal antibody 4H5 recognizes human Ficolin-3, also known as H-ficolin. Ficolins are a type of pattern recognition molecules that contain both collagen-like domains and fibrinogen-like domains, which can activate the complement system on the surface of microorganisms by binding to MASP. In humans, three types of Ficolins are known: Ficolin-1 (M-ficolin), Ficolin-2 (L-ficolin) and Ficolin-3 (H-ficolin). Ficolin-1 is mainly expressed by monocytes, granulocytes and lung cells, and is locally present in the inflammation area. Ficolin-3 (also known as Bodo Antigen, H-ficolin or Ficolin H) is produced by the liver and lungs. Ficolin-3 is associated with three types of MASP and sMAP, and the complex activates C4, C2 and C3 in the liquid phase.
Disease
Cardiology and metabolism, Infectious diseases
Size
100 µg
Immunogen
Infectious diseases
Species
Human
Clonality
Monoclonal
Clone Number
4H5
Buffer
PBS, containing 0.02% sodium azide and 0.1% bovine serum albumin.
Application
Frozen sections, Immuno assays, Immuno precipitation
Application Notes
The diluent used depends on the detection system used. It is recommended that users test reagents and determine their own optimal dilution. The typical initial working dilution is 1:50.
Storage Instructions
Product should be stored at 4°C. Under recommended storage conditions, product is stable for at least one year.
Alternative Names
FCN3; FCNH; HAKA1; ficolin 3
