Connect with Us at the Upcoming Events

With in-person events back again, Creative Biolabs is excited to greet you at the upcoming international conferences. Meet our team at 2022 BIO International Convention in June (booth #1754) and at the 13th Annual World ADC San Diego in September (booth number to be updated) for expert consultation on your drug discovery. Shoot an email to arrange an in-person meeting!

Book a Meeting

Anti-Human Ficolin-1 Monoclonal Antibody (clone 7G1) -0.5 mg (CAT#: CB-P343-AB) Datasheet

Product Type
Antibody
Description
Monoclonal antibody 7g1 recognizes human m-ficolin, also known as ficolin-1. Ficollins are a family of pattern recognition molecules, which contain both collagen like domain and fibrinogen like domain. They can activate the complement system on the surface of microorganisms by binding with MASPS. In humans, there are three known ficolins: m-ficolin, L-ficolin (ficolin-2) and h-ficolin (ficolin-3). M-ficolin was mainly expressed by monocytes, granulocytes and lung cells, and localized in the inflammatory area. However, this has recently been found in serum, suggesting that m-ficolin also plays a role in systemic immunity, just like L-and h-ficolin. Functional analysis of m-ficolin showed that its ligand was sialic acid, which existed in bacteria because the binding was eliminated when the bacteria were treated with sialidase. In addition, studies have shown that m-ficolin can promote the uptake of E.coli by leukemia monocyte lymphoma cells, which indicates that it acts as a phagocytic receptor on the surface of circulating monocytes. Low concentrations of m-ficolin in cord blood are associated with higher mortality associated with necrotizing enterocolitis, and two identified SNPs in the m-ficolin gene are associated with the development of rheumatoid arthritis. Monoclonal antibody 7g1 is suitable for immunoassay and Western blotting. -
Disease
Cardiology and metabolism, Infectious diseases
Size
100 µg
Immunogen
Full length recombinant M-Ficolin-
Species
Human
Host
Mouse
Clonality
Monoclonal
Isotype
Mouse IgG1
Clone Number
7G1
Buffer
PBS, containing 0.1% bovine serum albumin and 0.02% sodium azide.
Application
Flow cytometry, Immuno assays, Western blot
Application Notes
For immunoassays and western blotting, the diluent to be used depends on the detection system used. It is recommended that users test reagents and determine their own optimal dilution. The typical initial working dilution is 1:50. For functional studies, the in vitro dilution must be optimized in the user's experimental setting.
Storage Instructions
Product should be stored at 4°C. Under recommended storage conditions, product is stable for at least one year.
Target
Ficolin-1
Alternative Names
Ficolin-1; ficolin/P35-related

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

  • *
  • *
  • *
USA

UK