Anti-Human Complement factor D Monoclonal Antibody (clone D10/4) -100 µg (CAT#: CB-P177-AB) Datasheet

Antibody

The monoclonal antibody D10/4 recognizes human complement factor D. Factor D is another 27 kDa serine protease of the complement pathway, which is synthesized as a precursor single-chain molecule. The alternative complement pathway represents an important body fluid component that naturally defends against microbial attack. The involvement of alternative complement pathways has been involved in the pathogenesis of many human diseases. Factor D is unique among serine proteases because it does not require enzyme cleavage to express proteolytic activity, nor does it require activation of serine protease inhibitors to control it. Factor D is highly specific and cleaves factor B that binds to C3b, thereby generating C3bBb enzyme. Factor D is the rate-limiting C3 convertase of the alternative pathway. It has the lowest plasma concentration and lowest molecular weight of all complement components. The normal values ​​of human EDTA plasma and urine are 1.05 (±0.27) μg/ml and 0.62 (±0.33) μg/ml, respectively. In normal human subjects, factor D is rapidly eliminated by the kidneys. Compared with the control group, the levels of factor D in the plasma and urine of patients with renal failure increased. Plasma levels increase within seven days after successful kidney transplantation and return to normal levels to prevent excessive stimulation of the complement pathway. Human lipase is a protein expressed at high levels in adipose tissue, which is the same as factor D, and also shows the same enzymatic activity as factor D. This indicates that the role of factor D in adipose tissue is different from its role as a complement protein.

Infectious diseases, Nephrology