Product Type
Antibody
Description
Single colon antibody 9 (also known as YB2/90-5-20) reacts with neoantigens on iC3, iC3b, C3dg and C3g. However, C3g itself is a small fragment that may not be formed in the body. The complement system is an important factor in innate immunity. The third complement component, C3, is essential to the classical, alternative and lectin pathways of complement activation. The activation products of the complement cascade contain new epitopes that are not present in various natural components. The synthesis of C3 is tissue-specific and is regulated in response to a variety of stimulants. C3 is the most abundant protein in the complement system, and the serum protein level is about 1.3 mg/ml. Inherited C3 deficiency makes people prone to bacterial infections. C3 fragments are deposited in tissues at the site of antibody-mediated immunopathology. In ulcerative colitis and idiopathic chronic inflammatory bowel disease, the deposition of C3 in the diseased mucosa has been reported. The proteolysis of C3 convertase cleaves C3 into C3a and C3b. C3b attaches to the immune complex and is further cleaved into iC3b and C3f. iC3b is further processed into C3c and C3dg. C3dg can be cleaved into C3d and C3g, although this does not occur in plasma. Monoclonal antibody 9 recognizes iC3b, C3dg and C3g in plasma. The monoclonal antibody does not recognize C3 or C3b.
Disease
Infectious diseases, Nephrology
Size
100 µg
Species
Human
Clonality
Monoclonal
Clone Number
9
Buffer
PBS, containing 0.02% sodium azide and 0.1% bovine serum albumin.
Application
Immuno assays, Immuno precipitation
Application Notes
The diluent used depends on the detection system used. It is recommended that users test reagents and determine their own optimal dilution. The typical initial working dilution is 1:50.
Storage Instructions
Product should be stored at 4°C. Under recommended storage conditions, product is stable for at least one year.
Alternative Names
Complement 3 glomerulopathy; C3 Glomerulopathy
