Description
Anti-Human CD47 (Magrolimab)-Fc silent antibody is derived from clone Iodine, which is a Murine monoclonal antibody targeting the CD45. And it is intended for the research of Ablation of bone marrow prior to hematopoietic cell transplantation in AML patients .
Research Area
Cell Biology, Immunology,
Antigen Distribution
Ubiquitous expression in lung (RPKM 24.2), brain (RPKM 20.9) and 24 other tissues.
Disease
Myelodysplastic syndromes
Application Notes
The use of diluent depends on the detection system used. It is recommended that users test reagents and determine their own optimal dilution.
Handling Advice
This product is for research use only. It is not intended for use in therapeutic or diagnostic procedures for humans or animals.
Storage Instructions
Product should be stored at -80°C. Repeated freeze and thaw cycles will cause loss of activity. Use product within 24 hours after thawing and keep on ice. Remainder amounts should be aliquoted and immediately re-freezed for future use. Aliquots should never be thawed more than once. Under recommended storage conditions, product is stable for at least one year.
Background
This gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. The encoded protein is also a receptor for the C-terminal cell binding domain of thrombospondin, and it may play a role in membrane transport and signal transduction. This gene has broad tissue distribution, and is reduced in expression on Rh erythrocytes. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2010]
Alternative Names
CD47; CD47 molecule; IAP; OA3; MER6
