Product Type
Fc Silent Antibody
Description
Anti-Human CD40-Fc silent antibody is derived from clone BMS-986090, which is a Human monoclonal antibody targeting the CD40. And it is intended for the research of Autoimmune diseases, B cell malignancies.
Research Area
Cell Biology, Immunology
Antigen Distribution
Broad expression in lymph node (RPKM 19.2), appendix (RPKM 13.7) and 23 other tissues.
Disease
Autoimmune diseases, B cell malignancies
Immunogen
Recombinant Human CD40 protein
Application
Funcs, In vivo assay
Application Notes
The use of diluent depends on the detection system used. It is recommended that users test reagents and determine their own optimal dilution.
Handling Advice
This product is for research use only. It is not intended for use in therapeutic or diagnostic procedures for humans or animals.
Storage Instructions
Product should be stored at -80°C. Repeated freeze and thaw cycles will cause loss of activity. Use product within 24 hours after thawing and keep on ice. Remainder amounts should be aliquoted and immediately re-freezed for future use. Aliquots should never be thawed more than once. Under recommended storage conditions, product is stable for at least one year.
Official Name
CD40 molecule
Background
This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2014]
Alternative Names
CD40 molecule; B cell surface antigen CD40; B cell-associated molecule; CD40 molecule; TNF receptor superfamily member 5; CD40L receptorp50; Bp50; CDW40; TNFRSF5
