Product Type
Fc Silent Antibody
Description
Anti-Human CD257-Fc silent antibody is derived from clone Tabalumab, which is a Human monoclonal antibody targeting the CD257. And it is intended for the research of Autoimmune diseases, B cell malignancies.
Research Area
Cell Biology, Immunology
Antigen Distribution
BAFF is expressed on various cell types including monocytes, dendritic cells and bone marrow stromal cells.
Disease
Autoimmune diseases, B cell malignancies
Immunogen
Recombinant Human CD257 protein
Cross reactivity
Cynomolgus Monkey, Rabbit
Application
ELISA, FuNeutcS, FC, IF, IP, Neut, WB
Application Notes
The use of diluent depends on the detection system used. It is recommended that users test reagents and determine their own optimal dilution.
Handling Advice
This product is for research use only. It is not intended for use in therapeutic or diagnostic procedures for humans or animals.
Storage Instructions
Product should be stored at -80°C. Repeated freeze and thaw cycles will cause loss of activity. Use product within 24 hours after thawing and keep on ice. Remainder amounts should be aliquoted and immediately re-freezed for future use. Aliquots should never be thawed more than once. Under recommended storage conditions, product is stable for at least one year.
Official Name
Tumor necrosis factor ligand superfamily member 13B
Full Name
Tumor necrosis factor ligand superfamily member 13B
Background
BAFF is a membrane-bound, type II transmembrane protein that belongs to the tumor necrosis factor (TNF) ligand family and is the ligand for BR3, TACI, and BCMA. BAFF is an immunostimulant necessary for maintaining normal immunity. This cytokine has also been shown to play an important role in the proliferation and differentiation of B cells. An inadequate level of BAFF leads to immunodeficiency whilst an elevated level of BAFF causes unusually high antibody production that results in the development of autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis. Additionally, BAFF has been found in renal transplant biopsies with acute rejection. Furthermore, BAFF may be a mediator of food-related inflammation, and is associated with multiple dietary ailments including celiac disease, insulin resistance, diabetes, and obesity. Interestingly, it is suspected that BAFF may be involved in non-IgE-mediated reactions because there is no known correlation between BAFF and IgE.
Alternative Names
DTL; BLYS; TALL1; THANK; ZTNF4; TALL-1; TNLG7A; TNFSF20; TNFSF13B
