Product Type
Fc Silent Antibody
Description
Anti-Human CD25-Fc silent antibody is a Human monoclonal antibody targeting the CD25. And it is intended for the research of Autoimmune diseases.
Research Area
Cell Biology, Immunology
Antigen Distribution
IL-2Rα is expressed on activated mature T and B lymphocytes, during early stages of thymocytes development, pre-B cells, and in activated CD4+ memory T-lymphocytes.
Disease
Autoimmune diseases
Immunogen
Recombinant Human CD25 protein
Cross reactivity
Rhesus Monkey, Cynomolgus Monkey
Application
Block, FC, IF, IHC, WB
Application Notes
The use of diluent depends on the detection system used. It is recommended that users test reagents and determine their own optimal dilution.
Handling Advice
This product is for research use only. It is not intended for use in therapeutic or diagnostic procedures for humans or animals.
Storage Instructions
Product should be stored at -80°C. Repeated freeze and thaw cycles will cause loss of activity. Use product within 24 hours after thawing and keep on ice. Remainder amounts should be aliquoted and immediately re-freezed for future use. Aliquots should never be thawed more than once. Under recommended storage conditions, product is stable for at least one year.
Official Name
Interleukin-2 receptor subunit alpha
Full Name
Interleukin-2 receptor subunit alpha
Background
CD25, a 55 kD type I transmembrane glycoprotein, has been shown to play roles in lymphocyte differentiation, activation, and proliferation. Many resting memory T cells constitutively express IL2Rα. It functions as the receptor for HTLV-1, resulting in its expression on neoplastic cells in adult T cell lymphoma/leukemia. CD25 (sIL-2R) has been used to track disease progression. Some additional clinical applications include Chagas disease, a disease characterized by a decline of CD25 expression on immune cells, and Multiple sclerosis, in which treatments with mAbs target CD25.
Alternative Names
IL-2-RA; IL2-RA; TAC antigen; p55; CD25
