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Anti-Human C5aR Monoclonal Antibody (clone S5/1) -10 mg (CAT#: CB-P495-K) Datasheet

Product Type
Antibody
Description
Monoclonal antibody S5/1 recognizes the human receptor of C5a (CD88). The C5a receptor is a 45kDa transmembrane GTP-binding protein-coupled receptor with high affinity to human anaphylactoxin C5a. After C5a is bound, G The beginning of protein-dependent cellular responses, such as increased intracellular Ca2+, fusion with cell membrane particles, release of enzymes and explosion of oxidation, suggesting that C5aR is an important mediator of inflammation. C5a receptors are expressed in many cell types, including -neutral Granulocytes, monocytes/macrophages, dendritic cells, astrocytes and microglia.
Interestingly, C5a receptor signal transduction has been associated with several inflammatory diseases, including rheumatoid arthritis.
The clone S5/1 was generated against a synthetic peptide (Met1-Asn31) containing the N-terminal domain of C5aR. This antibody has been shown to inhibit the binding of C5a to its receptor.
Size
100 µg
Cross reactivity
Rabbit

All products and services are for Research Use Only. Do Not use in humans.

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Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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