Anti-Human C5aR Monoclonal Antibody (clone S5/1) -10 mg (CAT#: CB-P495-K) Datasheet

Antibody

Monoclonal antibody S5/1 recognizes the human receptor of C5a (CD88). The C5a receptor is a 45kDa transmembrane GTP-binding protein-coupled receptor with high affinity to human anaphylactoxin C5a. After C5a is bound, G The beginning of protein-dependent cellular responses, such as increased intracellular Ca2+, fusion with cell membrane particles, release of enzymes and explosion of oxidation, suggesting that C5aR is an important mediator of inflammation. C5a receptors are expressed in many cell types, including -neutral Granulocytes, monocytes/macrophages, dendritic cells, astrocytes and microglia.
Interestingly, C5a receptor signal transduction has been associated with several inflammatory diseases, including rheumatoid arthritis.
The clone S5/1 was generated against a synthetic peptide (Met1-Asn31) containing the N-terminal domain of C5aR. This antibody has been shown to inhibit the binding of C5a to its receptor.