Anti-HSP65 Antibody, Non-Fucosylated (VH2/VK3) (CAT#: BioBet-1014ZP) Datasheet

HSPD1

heat shock 60kDa protein 1 (chaperonin)

This gene encodes a member of the chaperonin family. The encoded mitochondrial protein may function as a signaling molecule in the innate immune system. This protein is essential for the folding and assembly of newly imported proteins in the mitochondria. This gene is adjacent to a related family member and the region between the 2 genes functions as a bidirectional promoter. Several pseudogenes have been associated with this gene. Two transcript variants encoding the same protein have been identified for this gene. Mutations associated with this gene cause autosomal recessive spastic paraplegia 13.

HSPD1; heat shock 60kDa protein 1 (chaperonin); HLD4; CPN60; GROEL; HSP60; HSP65; SPG13; HSP-60; HuCHA60; 60 kDa heat shock protein, mitochondrial; chaperonin 60; 60 kDa chaperonin; heat shock protein 65; P60 lymphocyte protein; mitochondrial matrix protein P1; short heat shock protein 60 Hsp60s1

Mitochondrion

Diseases associated with HSPD1 include Spastic Paraplegia 13, Autosomal Dominant and Leukodystrophy, Hypomyelinating, 4.

Its related pathways are Tuberculosis and Validated targets of C-MYC transcriptional activation.

Chaperone proteins are involved in mitochondrial protein import and macromolecular assembly. Together with Hsp10, it promotes the correct folding of the imported protein. It can also prevent misfolding and correct assembly of unfolded polypeptides produced under stress conditions in the mitochondrial matrix. The functional units of these chaperone proteins are composed of seven americ loops of the large subunit Hsp60, which function as a back-to-back double loop. In the cyclic reaction, each loop of the Hsp60 loop complex binds to an unfolded substrate protein, then binds to ATP and binds to the two heptameric loops of the Hsp10 parachaperone protein. This results in the substrate protein being isolated in the lumen of Hsp60, where it can fold for a period of time without interference from other cellular components. The simultaneous hydrolysis of ATP in all Hsp60 subunits leads to the dissociation of the chaperone protein loop and the release of ADP and folding substrate proteins (possibly).

Controls and Markers antibody; Signaling Transduction antibody; Mitochondrial Marker antibody

1.Ubiquitination at Lys31, Lys58, Lys72, Lys75, Lys82, Lys96, Lys125, Lys130, Lys133, Lys160, Lys191, Lys218, Lys233, Lys250, Lys292, Lys352, Lys469, and Lys481 2.Modification sites at PhosphoSitePlus

Protein Based Therapies
Monoclonal antibody (mAb)

IgG

VH2/VK3

Humanized

Human

The humanized antibody that specifically bind a HSP65 derived peptide are useed for the treatment of immune-related disorders, specifically, inflammatory disorders such as arthritis, IBD, psoriasis, diabetes and MS.

Inflammatory Diseases

Inflammatory Diseases