Description
Anti-HSP65 Antibody, Non-Fucosylated (BioBet-1014ZP) is a humanized monoclonal IgG antibody against HSP65. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Inflammatory Diseases
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced HSP65 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
HSPD1
Full Name
heat shock 60kDa protein 1 (chaperonin)
Background
This gene encodes a member of the chaperonin family. The encoded mitochondrial protein may function as a signaling molecule in the innate immune system. This protein is essential for the folding and assembly of newly imported proteins in the mitochondria. This gene is adjacent to a related family member and the region between the 2 genes functions as a bidirectional promoter. Several pseudogenes have been associated with this gene. Two transcript variants encoding the same protein have been identified for this gene. Mutations associated with this gene cause autosomal recessive spastic paraplegia 13.
Alternative Names
HSPD1; heat shock 60kDa protein 1 (chaperonin); HLD4; CPN60; GROEL; HSP60; HSP65; SPG13; HSP-60; HuCHA60; 60 kDa heat shock protein, mitochondrial; chaperonin 60; 60 kDa chaperonin; heat shock protein 65; P60 lymphocyte protein; mitochondrial matrix protein P1; short heat shock protein 60 Hsp60s1
Gene ID
3329
UniProt ID
Q9UK05
Cellular Localization
Mitochondrion
Involvement in Disease
Diseases associated with HSPD1 include Spastic Paraplegia 13, Autosomal Dominant and Leukodystrophy, Hypomyelinating, 4.
Related Pathways
Its related pathways are Tuberculosis and Validated targets of C-MYC transcriptional activation.
Function
Chaperone proteins are involved in mitochondrial protein import and macromolecular assembly. Together with Hsp10, it promotes the correct folding of the imported protein. It can also prevent misfolding and correct assembly of unfolded polypeptides produced under stress conditions in the mitochondrial matrix. The functional units of these chaperone proteins are composed of seven americ loops of the large subunit Hsp60, which function as a back-to-back double loop. In the cyclic reaction, each loop of the Hsp60 loop complex binds to an unfolded substrate protein, then binds to ATP and binds to the two heptameric loops of the Hsp10 parachaperone protein. This results in the substrate protein being isolated in the lumen of Hsp60, where it can fold for a period of time without interference from other cellular components. The simultaneous hydrolysis of ATP in all Hsp60 subunits leads to the dissociation of the chaperone protein loop and the release of ADP and folding substrate proteins (possibly).
Field of research
Controls and Markers antibody; Signaling Transduction antibody; Mitochondrial Marker antibody
Post-translational modifications
1.Ubiquitination at Lys31, Lys58, Lys72, Lys75, Lys82, Lys96, Lys125, Lys130, Lys133, Lys160, Lys191, Lys218, Lys233, Lys250, Lys292, Lys352, Lys469, and Lys481 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
VH2/VK3
Description
The humanized antibody that specifically bind a HSP65 derived peptide are useed for the treatment of immune-related disorders, specifically, inflammatory disorders such as arthritis, IBD, psoriasis, diabetes and MS.
Antibody Indication
Inflammatory Diseases
