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Anti-HS6ST2 Antibody, Non-Fucosylated (BioBet-1006ZP) (CAT#: BioBet-1006ZP) Datasheet

Target
HS6ST2
Isotype
IgG1
Description
ADCC-Enhanced anti-HS6ST2 (C10) is a non-fucosylated therapeutic biobetter antibody engineered by Creative Biolabs' Afuco™ technology platform.
Antibody Indication
Cancer
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced HS6ST2 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
HS6ST2
Full Name
heparan sulfate 6-O-sulfotransferase 2
Background
Heparan sulfate proteoglycans are ubiquitous components of the cell surface, extracellular matrix, and basement membranes, and interact with various ligands to influence cell growth, differentiation, adhesion, and migration. This gene encodes a member of the heparan sulfate (HS) sulfotransferase gene family, which catalyze the transfer of sulfate to HS. Different family members and isoforms are thought to synthesize heparan sulfates with tissue-specific structures and functions. Multiple transcript variants encoding different isoforms have been found for this gene.
Alternative Names
HS6ST2; heparan sulfate 6-O-sulfotransferase 2; heparan-sulfate 6-O-sulfotransferase 2; HS6ST-2
Gene ID
90161
UniProt ID
Q9UK05
Cellular Localization
Membrane
Involvement in Disease
Diseases associated with HS6ST2 include Paganini-Miozzo Syndrome and Cartilage Cancer.
Related Pathways
Its related pathways are Cytochrome P450 - arranged by substrate type and heparan sulfate biosynthesis.
Function
6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.
Post-translational modifications
1.Glycosylation at Asn209, Asn404, Asn460, Thr528, Asn544, Asn556, Asn564, Asn589, and Asn592 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG1
Antibody Clone
C10
Host
Mouse
Species Reactivity
Human
Description
The antibody that bind to HS6ST2 proteins are used for diagnosing cancer, HS6ST2 proteins conjugated to cytotoxic agents and pharmaceutical compositions comprising the HS6ST2 proteins as active ingredients.
Antibody Indication
Cancer

Cancer

Related Products

Anti-HS6ST2 Antibody, Non-Fucosylated (BioBet-1007ZP) (CAT#: BioBet-1007ZP)
Anti-HS6ST2 Antibody, Non-Fucosylated (BioBet-1005ZP) (CAT#: BioBet-1005ZP)

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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