Anti-HLA DR beta Antibody, Non-Fucosylated (CAT#: BioBet-254ZP) Datasheet

HLA-DRB1

Major Histocompatibility Complex, Class II, DR Beta 1

HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa. It is encoded by 6 exons. Exon one encodes the leader peptide; exons 2 and 3 encode the two extracellular domains; exon 4 encodes the transmembrane domain; and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogs DRB3, DRB4 and DRB5. DRB1 is present in all individuals. Allelic variants of DRB1 are linked with either none or one of the genes DRB3, DRB4 and DRB5. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9. [provided by RefSeq, Jul 2008]

Apolizumab;267227-08-7;1D10;HU1D10;K8-355;HLA-DRB1;major histocompatibility complex, class II, DR beta 1;HLA DR1B;DW2.2/DR2.2;MHC class II antigen;lymphocyte antigen DRB1;MHC class II HLA-DRw10-beta;human leucocyte antigen DRB1;MHC class II HLA-DR beta 1

Plasma membrane, Lysosome, Golgi apparatus, Endosome, Endoplasmic reticulum

Diseases associated with HLA-DRB1 include Sarcoidosis 1 and Multiple Sclerosis.

Its related pathways are TCR Signaling (Qiagen) and Tuberculosis.

1.The antigen presents the beta chain of the major histocompatibility complex II (MHCII) molecule. Complex with HLA-DRA chain, display antigen peptides on professional antigen-presenting cells (APCs) for recognition by -beta T cell receptor (TCR) on hla-drb1-restricted cd4-positive T cells. This will guide antigen-specific T helper effector functions, including antibody-mediated immune response and macrophage activation, and ultimately eliminate infectious agents and transformed cells. 2.Allele DRB1*01:01: shows an immunodominant epitope derived from Bacillus anthracis pagA/protective antigen PA (KLPLYISNPNYKVNVYAVT) for initial and PA-specific memory cd4 positive T cells. 3.Allele DRB1*03:01: may provide T-helper 1 cells with a HRV-16 epitope derived from the capsid protein VP2 (NEKQPSDDNWLNFDGTLLGN) to help clear the virus. Shows autopeptides from retinal SAG (NRERRGIALDGKIKHE) and thyroid TG (LSSVVVDPSIRHFDV).

Immune System antibody

1.Ubiquitinated by MARCH1 and MARCH8 at Lys-254 leading to sorting into the endosome system and down-regulation of MHCII 2.Glycosylation at Asn48 3.Ubiquitination at Lys254

Protein Based Therapies
Monoclonal antibody (mAb)

IgG1

BioBet-254ZP

Humanized

Human

Recombinant monoclonal antibody to HLA DR beta.

Chronic lymphocytic leukemia (CLL) (refractory)

Chronic lymphocytic leukemia (CLL) (refractory)