Description
Anti-Histone H2B Antibody, Non-Fucosylated (BioBet-959ZP) is a humanized monoclonal IgG antibody against Histone H2B. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Autoimmune Disease
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Histone H2B antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Full Name
H2B histone family, member M
Alternative Names
H2BFM; H2B histone family, member M; histone H2B type F-M; H2B/s; histone H2B.s
Cellular Localization
Nucleus
Related Pathways
Its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Viral carcinogenesis.
Function
The core component of nucleosomes. Nucleosomes wrap and compress DNA into chromatin, limiting DNA access to cellular mechanisms that require DNA as a template. Therefore, histones play a central role in transcriptional regulation, DNA repair, DNA replication and chromosome stability. DNA accessibility is regulated by a complex set of post-translational modifications of histones (also known as histone coding) and nucleosome remodeling.
Post-translational modifications
1.Modification sites at neXtProt 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Clone
BioBet-959ZP
Description
The antibody bind to a human histone protein, such as H2B, H3 or H4 are of use to treat a variety of diseases that may be associated with histones, such as autoimmune disease, atherosclerosis, arthritis, rheumatoid arthritis, edema, sepsis, septic shock, hyperinflammatory disorder, infectious disease, inflammatory disease, immune dysregulatory disorder, GVHD, transplant rejection, atherosclerosis, asthma, a coagulopathy, myocardial ischemia, thrombosis, nephritis, inflammatory liver injury, acute pancreatitis, ischemia-reperfusion injury, stroke, cardiovascular disease, and burn.
Antibody Indication
Autoimmune Disease
