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Anti-Histone H1 Antibody, Non-Fucosylated (1F5) (CAT#: BioBet-985ZP) Datasheet

Target
Histone H1
Isotype
IgG
Description
Anti-Histone H1 Antibody, Non-Fucosylated (BioBet-985ZP) is a human monoclonal IgG antibody against Histone H1. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Transplant Rejection
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Histone H1 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
Histone H1
Full Name
Histone H1
Background
Histone H1 is one of the five main histone protein families which are components of chromatin in eukaryotic cells. Though highly conserved, it is nevertheless the most variable histone in sequence across species.
Alternative Names
Histone H1
UniProt ID
Q9UK05
Cellular Localization
Nucleus
Involvement in Disease
Diseases associated with H1-0 include Hyperoxaluria, Primary, Type I and Spherocytosis, Type 1.
Related Pathways
Its related pathways are Activation of cAMP-Dependent PKA and Granzyme-A Pathway.
Function
Histone H1 is necessary for the condensation of nucleosomal chains into higher-order structures. Histone H1.0 is present in cells with a low rate of cell division at the end of differentiation.
Post-translational modifications
Phosphorylated on Ser-17 in RNA edited version. ADP-ribosylated on Ser-104 in response to DNA damage.
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
1F5
Host
Human
Species Reactivity
Human
Description
The anti-histone H1 monoclonal antibody are useful for suppressing, predicting, or diagnosing transplant rejection in organ transplantation.
Antibody Indication
Transplant Rejection

Transplant Rejection

Related Products

Anti-Histone H1 Antibody, Non-Fucosylated (16G9) (CAT#: BioBet-987ZP)
Anti-Histone H1 Antibody, Non-Fucosylated (15F11) (CAT#: BioBet-986ZP)

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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