Anti-HGF Fc Silent Antibody (Ficlatuzumab) (CAT#: FCS-252P) Datasheet

Human

Monoclonal

Human IgG1, κ

Ficlatuzumab

Unconjugated

Recombinant

PBS, pH 7.4

Funcs, In vivo assay

The use of diluent depends on the detection system used. It is recommended that users test reagents and determine their own optimal dilution.

Product should be stored at -20°C. Repeated freeze and thaw cycles will cause loss of activity. Use product within 24 hours after thawing and keep on ice. Remainder amounts should be aliquoted and immediately re-freezed for future use. Aliquots should never be thawed more than once. Under recommended storage conditions, product is stable for at least one year.

HGF

HGF

Hepatocyte Growth Factor

This gene encodes a protein that binds to the hepatocyte growth factor receptor to regulate cell growth, cell motility and morphogenesis in numerous cell and tissue types. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate alpha and beta chains, which form the mature heterodimer. This protein is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. This protein also plays a role in angiogenesis, tumorogenesis, and tissue regeneration. Although the encoded protein is a member of the peptidase S1 family of serine proteases, it lacks peptidase activity. Mutations in this gene are associated with nonsyndromic hearing loss. [provided by RefSeq, Nov 2015]

HGF; hepatocyte growth factor (hepapoietin A; scatter factor); deafness; autosomal recessive 39; DFNB39; hepatocyte growth factor; F TCF; fibroblast derived tumor cytotoxic factor; hepatopoietin A; HGFB; HPTA