Anti-HGF Antibody, Highly Galactosylated (CAT#: BioBet-GA-250ZP) Datasheet

HGF

Hepatocyte Growth Factor

This gene encodes a protein that binds to the hepatocyte growth factor receptor to regulate cell growth, cell motility and morphogenesis in numerous cell and tissue types. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate alpha and beta chains, which form the mature heterodimer. This protein is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. This protein also plays a role in angiogenesis, tumorogenesis, and tissue regeneration. Although the encoded protein is a member of the peptidase S1 family of serine proteases, it lacks peptidase activity. Mutations in this gene are associated with nonsyndromic hearing loss. [provided by RefSeq, Nov 2015]

Rilotumumab; 872514-65-3; AMG 102; 2.12.1; Rmab; HGF; hepatocyte growth factor (hepapoietin A; scatter factor); deafness, autosomal recessive 39, DFNB39; hepatocyte growth factor; F TCF; fibroblast derived tumor cytotoxic factor; hepatopoietin A; HGFB; HPTA;

Extracellular region or secreted

Its related pathways are RET signaling and Signaling by GPCR.

The potent mitogen of mature parenchymal hepatocytes appears to be a liver trophic factor and as a growth factor for a wide range of tissues and cell types. It activates receptor ligands by binding to receptor tyrosine kinases and promoting its dimerization.

1.Glycosylation at Asn294, Asn402, Thr476, Asn566, and Asn653 2.Modification sites at PhosphoSitePlus 3.Glycosylation from GlyConnect

Protein Based Therapies
Monoclonal antibody (mAb)

IgG2, κ

BioBet-GA-250ZP

Human

Human

This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody Fragment Fab to HGF. Rilotumumab is a human monoclonal antibody designed for the treatment of solid tumors.

Cancers

Cancers