Anti-Heparanase Antibody, Non-Fucosylated (BioBet-1004ZP) (CAT#: BioBet-1004ZP) Datasheet

HPSE

heparanase

Heparan sulfate proteoglycans are major components of the basement membrane and extracellular matrix. The protein encoded by this gene is an enzyme that cleaves heparan sulfate proteoglycans to permit cell movement through remodeling of the extracellular matrix. In addition, this cleavage can release bioactive molecules from the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene.

HPSE; heparanase; HPA; HPA1; HPR1; HSE1; HPSE1; heparanase-1; endo-glucoronidase

Extracellular region or secreted, Nucleus, Lysosome

Diseases associated with HPSE include Kyphoscoliotic Heart Disease and Urofacial Syndrome 1.

Its related pathways are Glycosaminoglycan degradation and Proteoglycans in cancer.

Endoglycosidase that cleaves heparin sulfate proteoglycan into heparin sulfate side chain and core proteoglycan. Participate in the degradation and reconstruction of extracellular matrix (ECM). The connection between the glucuronic acid unit and the n-sulfoglucosamine unit is selectively cleaved, carrying a 3-o-sulfo group or a 6-o-sulfo group. The bond between glucuronic acid and n-sulfoglucosamine can also be cut, but the bond between glucuronic acid and 2-anthranilic acid glucosamine cannot be cut. It is basically inactive at neutral pH, but becomes active under acidic conditions such as tumor invasion and inflammation. Promote cell migration related to metastasis, wound healing and inflammation. Enhance the shedding of synthetic protein, increase the endothelial cell invasion and angiogenesis of myeloma. In the presence of tissue factor and activator VII, it acts as a coagulant by increasing the production of activator X. Increases cell adhesion to the extracellular matrix (ECM), independent of its enzymatic activity. Lipid raft induces phosphorylation of AKT1/PKB, which increases cell migration and invasion. Heparin increases the activation of AKT1/PKB. Regulate bone formation. By up-regulating src-mediated VEGF activation, angiogenesis is enhanced. The relationship between root sheath differentiation in hair follicles and hair homeostasis.

1.Proteolytically processed. The cleavage of the 65 kDa form leads to the generation of a linker peptide, and 8 kDa and 50 kDa products. The active form, the 8/50 kDa heterodimer, is resistant to degradation. Complete removal of the linker peptide appears to be a prerequisite to the complete activation of the enzyme 2.Modification sites at PhosphoSitePlus 3.N-glycosylated. Glycosylation of the 50 kDa subunit appears to be essential for its solubility 4.Glycosylation at Asn162, Asn178, Asn238, Asn200, Asn217, and Asn459

Protein Based Therapies
Monoclonal antibody (mAb)

IgG

BioBet-1004ZP

Human

Human

This is a fully human antibody that binds to and neutralizes the heparanase I enzyme. Preclinical testing suggests that this antibody has the potential to prevent tumor growth and to reduce metastasis to limit the spread of tumors. This antibody to heparanase I, one of a family of heparanase molecules, has the potential to be used in the treatment of many tumors, including breast cancer.

Breast Cancer

Breast Cancer