Anti-Gremlin 1 Antibody, Non-Fucosylated (BioBet-954ZP) (CAT#: BioBet-954ZP) Datasheet

GREM1

gremlin 1, DAN family BMP antagonist

This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to relay the sonic hedgehog (SHH) signal from the polarizing region to the apical ectodermal ridge during limb bud outgrowth. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

GREM1; gremlin 1, DAN family BMP antagonist; DRM; HMPS; MPSH; PIG2; CRAC1; CRCS4; DAND2; HMPS1; IHG-2; DUP15q; C15DUPq; GREMLIN; CKTSF1B1; gremlin-1; gremlin 1-like protein; DAN domain family member 2; increased in high glucose-2; colorectal adenoma and carcinoma 1; cell proliferation-inducing gene 2 protein; cysteine knot superfamily 1, BMP antagonist 1; gremlin 1, cysteine knot superfamily, homolog; down-regulated in Mos-transformed cells protein

Extracellular region or secreted

Diseases associated with GREM1 include Polyposis Syndrome, Hereditary Mixed, 1 and Hereditary Mixed Polyposis Syndrome.

Its related pathways are Signaling by BMP and TGF-beta signaling pathway (KEGG).

Cytokines may play an important role in tumorigenesis and metanephrogenesis, as BMP antagonists required to maintain the early limb growth and pattern formation in the FGF4-SHH feedback loop. Down-regulate BMP4 signal in a dose-dependent manner (through similarity). Opponent of BMP2; inhibits BMP-mediated differentiation of osteoblasts (in vitro). As an inhibitor of monocyte chemotaxis. When overexpressed (through similarity), it can inhibit the growth or viability of normal cells, but not transformed cells.

Developmental Biology antibody; Signaling Transduction antibody

Protein Based Therapies
Monoclonal antibody (mAb)

IgG

H4H2780N

Human

Human

The antibody that bind to human gremlin-1 (GREM1 ) are used for treating a GREM1 -related disease or disorder such as fibrosis and cancer.

Cancer

Cancer