Description
ADCC-Enhanced anti-Gremlin 1 (H4H2780N) is a non-fucosylated therapeutic biobetter antibody engineered by Creative Biolabs' Afuco™ technology platform.
Antibody Indication
Cancer
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Gremlin 1 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
GREM1
Full Name
gremlin 1, DAN family BMP antagonist
Background
This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to relay the sonic hedgehog (SHH) signal from the polarizing region to the apical ectodermal ridge during limb bud outgrowth. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Alternative Names
GREM1; gremlin 1, DAN family BMP antagonist; DRM; HMPS; MPSH; PIG2; CRAC1; CRCS4; DAND2; HMPS1; IHG-2; DUP15q; C15DUPq; GREMLIN; CKTSF1B1; gremlin-1; gremlin 1-like protein; DAN domain family member 2; increased in high glucose-2; colorectal adenoma and carcinoma 1; cell proliferation-inducing gene 2 protein; cysteine knot superfamily 1, BMP antagonist 1; gremlin 1, cysteine knot superfamily, homolog; down-regulated in Mos-transformed cells protein
Gene ID
26585
UniProt ID
Q9UK05
Cellular Localization
Extracellular region or secreted
Involvement in Disease
Diseases associated with GREM1 include Polyposis Syndrome, Hereditary Mixed, 1 and Hereditary Mixed Polyposis Syndrome.
Related Pathways
Its related pathways are Signaling by BMP and TGF-beta signaling pathway (KEGG).
Function
Cytokines may play an important role in tumorigenesis and metanephrogenesis, as BMP antagonists required to maintain the early limb growth and pattern formation in the FGF4-SHH feedback loop. Down-regulate BMP4 signal in a dose-dependent manner (through similarity). Opponent of BMP2; inhibits BMP-mediated differentiation of osteoblasts (in vitro). As an inhibitor of monocyte chemotaxis. When overexpressed (through similarity), it can inhibit the growth or viability of normal cells, but not transformed cells.
Post-translational modifications
Developmental Biology antibody; Signaling Transduction antibody
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
H4H2780N
Description
The antibody that bind to human gremlin-1 (GREM1 ) are used for treating a GREM1 -related disease or disorder such as fibrosis and cancer.
Antibody Indication
Cancer
