Background
This gene encodes a member of the G protein-coupled receptor family described as an epididymis-specific transmembrane protein. The encoded protein may be proteolytically processed as it contains a motif shown to be a protein scission motif in some members of this family (PMID: 11973329). Multiple transcript variants encoding different isoforms have been found for this gene.
Alternative Names
GPR64; G protein-coupled receptor 64; HE6; EDDM6; TM7LN2; G-protein coupled receptor 64; epididymal protein 6; human epididymis-specific protein 6; G protein-coupled receptor, epididymis-specific (seven transmembrane family)
Involvement in Disease
Diseases associated with ADGRG2 include Vas Deferens, Congenital Bilateral Aplasia Of, X-Linked and Vas Deferens, Congenital Bilateral Aplasia Of.
Post-translational modifications
1.Proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit 2.Modification sites at PhosphoSitePlus 3.Highly glycosylated 4.Glycosylation at Asn44, Asn85, Asn111, Asn99, Asn117, Asn144, Asn162, Asn186, Asn194, Thr268, Ser271, Thr277, Asn357, Asn370, Asn435, Asn438, Asn456, Asn461, Asn597, Asn528, Asn542, Asn547, Asn551, and Asn857
