Anti-Gonadotropin releasing hormone Receptor Antibody, Non-Fucosylated (BioBet-938ZP) (CAT#: BioBet-938ZP) Datasheet

GNRHR

gonadotropin-releasing hormone receptor

This gene encodes the receptor for type 1 gonadotropin-releasing hormone. This receptor is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate. Following binding of gonadotropin-releasing hormone, the receptor associates with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Activation of the receptor ultimately causes the release of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH). Defects in this gene are a cause of hypogonadotropic hypogonadism (HH). Alternative splicing results in multiple transcript variants encoding different isoforms. More than 18 transcription initiation sites in the 5 region and multiple polyA signals in the 3 region have been identified for this gene.

GNRHR; gonadotropin-releasing hormone receptor; HH7; GRHR; LRHR; LHRHR; GNRHR1; gnRH-R; gnRH receptor; luliberin receptor; type I GnRH receptor; leutinizing-releasing hormone receptor; leutinizing hormone releasing horomone receptor; gonadotropin-releasing hormone (type 1) receptor 1

Plasma membrane

Diseases associated with GNRHR include Hypogonadotropic Hypogonadism 7 With Or Without Anosmia and Isolated Congenital Hypogonadotropic Hypogonadism.

Its related pathways are Integrin Pathway and RET signaling.

Gonadotropin-releasing hormone (GnRH) receptors mediate GnRH to stimulate the secretion of gonadotropins luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This receptor modulates its effects by linking with protein g, which activates the phosphatidylinositol-calcium second messenger system. Isoform 2 may act as an inhibitor of GnRH-R signaling.

Neuroscience antibody

1.Glycosylation at Asn18 and Asn102 2.Modification sites at PhosphoSitePlus

Protein Based Therapies
Monoclonal antibody (mAb)

IgG

BioBet-938ZP

Humanized

Human

Monoclonal antibody against gonadotropin releasing hormone (GnRH) receptor induce cellular apoptosis of various cancer cells expressing this surface receptor. The monoclonal antibody can serve as anti-cancer agents for the treatment of cancer in humans, and can function as analogs of GnRH to affect regulation of reproductive functions or fertility in humans.

Cancer

Cancer