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Anti-GMAD Antibody, Non-Fucosylated (BioBet-935ZP) (CAT#: BioBet-935ZP) Datasheet

Target
GMAD
Isotype
IgG
Description
Anti-GMAD Antibody, Non-Fucosylated (BioBet-935ZP) is a human monoclonal IgG antibody against GMAD. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Diabetes Mellitus
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced GMAD antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
GMAD
Full Name
GMAD
Background
A polypeptide known as GMAD (also known as Resistin) is specifically secreted by adipocytes, leading to a decrease in insulin action (like glucose transport), and a subsequent increase in adiposity in animal models. In addition, secretion of the GMAD polypeptide has been shown to lead to increased insulin resistance by adipocytes, whereas an inhibition of GMAD leads to an increase in insulin action and thus an increase in cellular glucose uptake.
Alternative Names
GMAD; Resistin
UniProt ID
Q9UK05
Cellular Localization
Extracellular region or secreted
Involvement in Disease
Diseases associated with RETN include Diabetes Mellitus, Noninsulin-Dependent and Acquired Generalized Lipodystrophy.
Related Pathways
Its related pathways are Common Cytokine Receptor Gamma-Chain Family Signaling Pathways and Innate Immune System.
Function
Hormone that seems to suppress insulin ability to stimulate glucose uptake into adipose cells (By similarity). Potentially links obesity to diabetes (By similarity). Promotes chemotaxis in myeloid cells
Post-translational modifications
No Post-translational modifications
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
BioBet-935ZP
Host
Human
Species Reactivity
Human
Description
The antibody that immunospecifically bind to GMAD have uses, for example, in the prevention and treatment of both insulin- and non insulin-dependent diabetes mellitus (i. e. Type I and Type II diabetes) and other related disorders.
Antibody Indication
Diabetes Mellitus

Diabetes Mellitus

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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