Target
Glucose Transporter GLUT8
Description
Anti-Glucose Transporter GLUT8 Antibody, Non-Fucosylated (BioBet-1294ZP) is a human monoclonal IgG antibody against Glucose Transporter GLUT8. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Cancer
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Glucose Transporter GLUT8 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Full Name
solute carrier family 2 (facilitated glucose transporter), member 8
Background
This gene belongs to the solute carrier 2A family, which includes intracellular glucose transporters. Based on sequence comparison, the glucose transporters are grouped into three classes and this gene is a member of class II. The encoded protein, like other members of the family, contains several conserved residues and motifs and 12 transmembrane domains with both amino and carboxyl ends being on the cytosolic side of the membrane. Alternatively spliced transcript variants have been described for this gene.
Alternative Names
SLC2A8; solute carrier family 2 (facilitated glucose transporter), member 8; GLUT8; GLUTX1; solute carrier family 2, facilitated glucose transporter member 8; glucose transporter type 8; glucose transporter type X1
Cellular Localization
Plasma membrane
Involvement in Disease
Diseases associated with SLC2A8 include Endometrial Clear Cell Adenocarcinoma.
Related Pathways
Its related pathways are Clathrin-mediated endocytosis and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds.
Function
Insulin-regulated facilitative hexose transporter that mediates the transport of glucose and fructose. Also able to mediate the transport of dehydroascorbate.
Post-translational modifications
1.Glycosylation at Asn349 2.Modification sites at PhosphoSitePlus 3.Ubiquitination at Lys465
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Description
VB1-050 is an IgG MAb generated from pooled lymphocytes of cancer patient samples, using standard hybridoma techniques. This antibody demonstrates preferential binding to a host of tumor cell lines, including breast, liver, prostate and colon, with limited normal tissue reactivity. Further research is ongoing to assess the potential clinical exploitation of VB1-050/Glut-8.
Antibody Indication
Cancer
