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Anti-Glucocorticoid-induced TNFR-related protein Antibody, Non-Fucosylated (BioBet-1381ZP) (CAT#: BioBet-1381ZP) Datasheet

Target
Glucocorticoid-induced TNFR-related protein
Isotype
IgG
Description
Anti-Glucocorticoid-induced TNFR-related protein Antibody, Non-Fucosylated (BioBet-1381ZP) is a humanized monoclonal IgG antibody against Glucocorticoid-induced TNFR-related protein. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Melanoma
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Glucocorticoid-induced TNFR-related protein antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
TNFRSF18
Full Name
tumor necrosis factor receptor superfamily, member 18
Background
This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Alternative Names
TNFRSF18; tumor necrosis factor receptor superfamily, member 18; AITR; GITR; CD357; GITR-D; tumor necrosis factor receptor superfamily member 18; activation-inducible TNFR family receptor; glucocorticoid-induced TNFR-related protein; TNF receptor superfamily activation-inducible protein
Gene ID
8784
Cellular Localization
Plasma membrane, Extracellular region or secreted
Involvement in Disease
Diseases associated with TNFRSF18 include Tropical Spastic Paraparesis and Diverticulitis.
Related Pathways
Its related pathways are TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions and Akt Signaling.
Function
TNFSF18 receptor. It seems to be involved in the interaction between activated T lymphocytes and endothelial cells, and regulate cell death mediated by T cell receptors. Nf-kpa-b activation mediated by TRAF2/NIK pathway
Post-translational modifications
Glycosylation at Asn146
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
BioBet-1381ZP
Host
Humanized
Species Reactivity
Human
Description
TRX518, a novel, humanized monoclonal antibody that is designed to enhance the immune system's anti-tumor response. TRX518 is the first GITR-targeted therapeutic to enter human studies. TRX518 is currently being investigated for the treatment of cancer in a Phase 1 clinical trial.
Antibody Indication
Melanoma

Melanoma

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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