Target
Glucocorticoid-induced TNF receptor (GITR)
Description
Anti-Glucocorticoid-induced TNF receptor Antibody, Non-Fucosylated (BioBet-1839ZP) is a human monoclonal IgG antibody against Glucocorticoid-induced TNF receptor (GITR). This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Unresectable Stage III or Stage IV Malignant Melanoma or Other Solid Tumor Malignancies
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Glucocorticoid-induced TNF receptor (GITR) antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Full Name
tumor necrosis factor receptor superfamily, member 18
Background
This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Alternative Names
TNFRSF18; tumor necrosis factor receptor superfamily, member 18; AITR; GITR; CD357; GITR-D; tumor necrosis factor receptor superfamily member 18; activation-inducible TNFR family receptor; glucocorticoid-induced TNFR-related protein; TNF receptor superfamily activation-inducible protein
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Clone
BioBet-1839ZP
Description
Non-Fucosylated Anti-Human Glucocorticoid-induced TNF receptor (GITR) (TRX518) is a glycosylation-modified therapeutic biobetter antibody.
Antibody Indication
Unresectable Stage III or Stage IV Malignant Melanoma or Other Solid Tumor Malignancies
