Product Type
Fc Silent Antibody
Description
The Fc-mediated effector functions of antibodies include antibody-dependent cellular cytotoxicity (ADCC), antibody-dependent cellular phagocytosis (ADCP), and complement-dependent cytotoxicity (CDC), and have been shown to be crucial for the therapeutic efficacy of most clinically approved antibodies. However, engaging immune effectors through FcγR and complement interactions may be detrimental to certain mAb mechanisms of action and so Fc-null or -silenced antibodies may be desired.
Creative Biolabs uses site-directed mutagenesis technology to generate Fc-silenced antibody with reduced effector functions. The mutated Fc domains eliminate the binding of Fc receptors (FcγR, FcR), thereby leading to a significant reduction in ADCC and CDC in comparison to WT IgG.
Immunogen
BSF-1 / IL-4 purified from serum-free supernatants of cultured EL-4 cells (a C57BL/6 thymoma) induced with 4β-phorbol 12β-myristate 12α-acetate for 48h.
Species
Mouse
Cross reactivity
Mouse
Clonality
Monoclonal
Clone Number
11B11
Conjugation
Unconjugated
Source
This is a chimeric antibody created to reduce immunogenicity during in vivo applications.
Buffer
PBS only
Application
EL, FC, in vivo, IHC
Storage Instructions
The products is formulated in PBS only without addition of preservatives. To ensure optimal storage and prevent microbial contamination, only open and dispense under s...
Alternative Names
TNFSF18, AITRL, GITRL, TL6, hGITRL, TNLG2A, tumor necrosis factor superfamily member 18, TNF superfamily member 18
