Anti-Ghrelin Antibody, Non-Fucosylated (D4) (CAT#: BioBet-923ZP) Datasheet

GHRL

growth hormone receptor

This gene encodes the ghrelin-obestatin preproprotein that is cleaved to yield two peptides, ghrelin and obestatin. Ghrelin is a powerful appetite stimulant and plays an important role in energy homeostasis. Its secretion is initiated when the stomach is empty, whereupon it binds to the growth hormone secretagogue receptor in the hypothalamus which results in the secretion of growth hormone (somatotropin). Ghrelin is thought to regulate multiple activities, including hunger, reward perception via the mesolimbic pathway, gastric acid secretion, gastrointestinal motility, and pancreatic glucose-stimulated insulin secretion. It was initially proposed that obestatin plays an opposing role to ghrelin by promoting satiety and thus decreasing food intake, but this action is still debated. Recent reports suggest multiple metabolic roles for obestatin, including regulating adipocyte function and glucose metabolism. Alternative splicing results in multiple transcript variants. In addition, antisense transcripts for this gene have been identified and may potentially regulate ghrelin-obestatin preproprotein expression.

GHRL; ghrelin/obestatin prepropeptide; MTLRP; appetite-regulating hormone; motilin-related peptide; ghrelin/obestatin preprohormone; growth hormone-releasing peptide; prepro-appetite regulatory hormone; ghrelin, growth hormone secretagogue receptor ligand

Extracellular region or secreted

Diseases associated with GHRL include Body Mass Index Quantitative Trait Locus 11 and Bulimia Nervosa.

Its related pathways are RET signaling and Signaling by GPCR.

Ghrelin is a ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary gland. It can stimulate appetite, induce obesity, and stimulate gastric acid secretion. Participate in growth regulation. Obestatin may be the ligand of GPR39. It may have the effect of reducing appetite, resulting in reduced food intake. Can reduce gastric emptying activity and jejunum movement (similar).

Cell Biology and Cellular Response antibody; Metabolism antibody; Neuroscience antibody; Signaling Transduction antibody

O-octanoylation or O-decanoylation is essential for ghrelin activity. The O-decanoylated forms Ghrelin-27-C10 and Ghrelin-28-C10 differ in the length of the carbon backbone of the carboxylic acid bound to Ser-26. A small fraction of ghrelin, ghrelin-28-C10:1, may be modified with a singly unsaturated carboxylic acid (PubMed:10604470). Amidation of Leu-98 is essential for obestatin activity.

Protein Based Therapies
Monoclonal antibody (mAb)

IgG

D4

Humanized

Human

The monoclonal antibody which bind acylated and unacylated human ghrelin are useful for neutralizing ghrelin activity and treating disorders in which ghrelin activity is detrimental, including obesity and related disorders, and various cancers.

Cancer

Cancer