Description
Anti-GDNF family receptor alpha 3 Antibody, Non-Fucosylated (BioBet-921ZP) is a human monoclonal IgG antibody against GDNF family receptor alpha 3. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Cancer
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced GDNF family receptor alpha 3 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
GFRA3
Full Name
GDNF family receptor alpha 2
Background
The protein encoded by this gene is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor and a member of the GDNF receptor family. It forms a signaling receptor complex with RET tyrosine kinase receptor and binds the ligand, artemin.
Alternative Names
GFRA3; GDNF family receptor alpha 3; GDNFR3; GDNF family receptor alpha-3; GFR-alpha-3; GDNFR-alpha-3; GPI-linked receptor; GDNF receptor alpha-3; glial cell line-derived neurotrophic factor receptor alpha-3
Gene ID
2676
UniProt ID
Q9UK05
Cellular Localization
Plasma membrane
Related Pathways
Its related pathways are GDNF-Family Ligands and Receptor Interactions and RET signaling.
Function
Receptor for the glial cell line-derived neurotrophic factor, ARTN (artemin). Mediates the artemin-induced autophosphorylation and activation of the RET receptor tyrosine kinase.
Post-translational modifications
N-glycosylated.
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
BioBet-921ZP
Description
The antibody that bind to the receptor GFRalpha3 are used to inhibit phosphorylation of Ret in a cell and treat disorders and in a subject.
Antibody Indication
Cancer
