Anti-GCGR Antibody, Non-Fucosylated (BioBet-910ZP) (CAT#: BioBet-910ZP) Datasheet

GCGR

glucagon

The protein encoded by this gene is a glucagon receptor that is important in controlling blood glucose levels. Defects in this gene are a cause of non-insulin-dependent diabetes mellitus (NIDDM).

GCGR; glucagon receptor; GGR; GL-R

Plasma membrane

Diseases associated with GCGR include Gcgr-Related Hyperglucagonemia and Diabetes Mellitus.

Its related pathways are RET signaling and Signaling by GPCR.

The g-protein coupled receptor of glucagon plays a central role in regulating blood glucose levels and blood glucose homeostasis. Regulate the rate of liver glucose production by promoting glycogen hydrolysis and gluconeogenesis. Play an important role in regulating fasting response. Ligand binding causes conformational changes, triggers signals through guanine nucleotide binding protein (G protein), and modulates the activity of downstream effectors, such as adenylate cyclase. Promote the activation of adenylate cyclase. In addition, the phosphatidylinositol-calcium second messenger system plays a role in signal transduction.

Cancer antibody; Metabolism antibody; Signaling Transduction antibody

Ligand-binding promotes phosphorylation of serine residues in the C-terminal cytoplasmic domain. Phosphorylation is important for receptor endocytosis after ligand-binding.

Protein Based Therapies
Monoclonal antibody (mAb)

IgG

BioBet-910ZP

Human

Human

This is a novel human monoclonal GCGR antibody, effectively lowered the glucose level in diabetic animal models with mild and reversible hyperglucagonemia. Suppression of excess HGP may be a promising therapeutic modality for the treatment of type 2 diabetes.

Diabetes Type 1; Diabetes Type 2

Diabetes Type 1; Diabetes Type 2