Description
Anti-ganglioside GD3 Antibody, Non-Fucosylated (BioBet-447ZP) is a mouse monoclonal IgG2b, κ antibody against ganglioside GD3. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Melanoma
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced ganglioside GD3 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
ST8SIA1
Alternative Names
mitumomab;216503-58-1;BEC-2;ST8SIA1;ST8 alpha-N-acetyl-neuraminide alpha-2, 8-sialyltransferase 1;sialyltransferase 8 (alpha N acetylneuraminate: alpha 2, 8 sialytransferase, GD3 synthase) A , SIAT8, SIAT8A;alpha-N-acetylneuraminide alpha-2, 8-sialyltrans
Gene ID
6489
UniProt ID
Q92185
Cellular Localization
Golgi apparatus
Involvement in Disease
Diseases associated with ST8SIA1 include Miller Fisher Syndrome.
Related Pathways
Its related pathways are Transport to the Golgi and subsequent modification and Glycosphingolipid biosynthesis - ganglio series.
Function
Involved in the production of gangliosides GD3 and GT3 from GM3; gangliosides are a subfamily of complex glycosphinglolipds that contain one or more residues of sialic acid.
Post-translational modifications
1.Glycosylation at Asn71, Asn119, Asn214, and Asn245 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG2b, κ
Antibody Clone
BioBet-447ZP
Description
ADCC-enhanced mitumomab is a non-fucosylated anti-ganglioside GD3 therapeutic biobetter antibody.
Antibody Indication
Melanoma
