Description
ADCC-Enhanced anti-Galanin (1G12) is a non-fucosylated therapeutic biobetter antibody engineered by Creative Biolabs' Afuco™ technology platform.
Antibody Indication
Hyperproliferative Disorders
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Galanin antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
GAL
Full Name
glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
Background
Galanin is small neuropeptide that functions as a cellular messenger within the central and peripheral nervous systems, modulating diverse physiologic functions (Mechenthaler, 2008 ).
Alternative Names
GAL; galanin/GMAP prepropeptide; GALN; GLNN; GMAP; GAL-GMAP; galanin peptides; galanin prepropeptide; galanin-related peptide; galanin-message-associated peptide
Gene ID
51083
Cellular Localization
Extracellular region or secreted
Involvement in Disease
Diseases associated with GAL include Epilepsy, Familial Temporal Lobe, 8 and Acute Endometritis.
Related Pathways
Its related pathways are Signaling by GPCR and Peptide ligand-binding receptors.
Function
An endocrine hormone of the central and peripheral nervous system that binds and activates the G protein-coupled receptors GALR1, GALR2 and GALR3. This small neuropeptide can regulate a variety of physiological functions, including the contraction of smooth muscles of the gastrointestinal and genitourinary tract, the release of growth hormone and insulin, and the secretion of adrenal glands.
Field of research
Cell Biology and Cellular Response antibody; Metabolism antibody; Neuroscience antibody
Post-translational modifications
1.Glycosylation at Thr35 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
1G12
Description
The antibody that immunospecifically bind to a galanin peptide are used for preventing, treating, managing, and/or ameliorating hyperproliferative disorders.
Antibody Indication
Hyperproliferative Disorders
Hyperproliferative Disorders
