Description
Anti-FZD8 Antibody, Non-Fucosylated (BioBet-1446ZP) is a human monoclonal IgG antibody against FZD8. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Cancer
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced FZD8 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
FZD8
Full Name
Frizzled-8
Background
Frizzled-8 is a protein that in humans is encoded by the FZD8 gene.
Alternative Names
FZD8, FZ-8, hFZ8, frizzled class receptor 8
Gene ID
8325
Cellular Localization
Golgi apparatus, Plasma membrane
Involvement in Disease
Diseases associated with FZD8 include Interstitial Cystitis and Exudative Vitreoretinopathy.
Related Pathways
Its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and Association Between Physico-Chemical Features and Toxicity Associated Pathways.
Function
Wnt protein receptor. The components of the Wnt-Fzd-LRP5-LRP6 complex trigger the -catenin signal by inducing the receptor ligand complex to aggregate into a ribosome-sized signal body. The typical signaling pathway of catenin leads to the activation of scatter proteins, the inhibition of GSK-3 kinase, the nuclear accumulation of catenin and the activation of Wnt target genes. A second signaling pathway involving PKC and calcium flux has been found in some family members, but it is not clear whether it represents a unique pathway or whether it can be integrated into the canonical pathway because of Wnt-mediated GSK-3 Kinase inactivation seems to require PKC. Both of these pathways seem to involve interaction with protein g. It may be involved in the formation of tissue morphology and/or the transduction of polarity information and cell-to-cell transmission in differentiated tissues. RYK and co-receptors for Wnt proteins (such as WNT1).
Field of research
Cancer antibody; Developmental Biology antibody; Signaling Transduction antibody
Post-translational modifications
Ubiquitinated by ZNRF3, leading to its degradation by the proteasome.
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
18R8
Description
The antibody binds to human frizzled receptor and confirmed to inhibit Wnt signaling and/or inhibit tumor growth.
Antibody Indication
Cancer
