Description
Anti-FZD1 Antibody, Non-Fucosylated (BioBet-1434ZP) is a human monoclonal IgG antibody against FZD1. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Cancer
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced FZD1 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
FZD1
Full Name
frizzled class receptor 1
Background
Frizzled-1 is a protein that in humans is encoded by the FZD1 gene.
Alternative Names
FZD1
Gene ID
8321
Cellular Localization
Plasma membrane
Involvement in Disease
Diseases associated with FZD1 include Exudative Vitreoretinopathy and Exudative Vitreoretinopathy 1.
Related Pathways
Its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and Association Between Physico-Chemical Features and Toxicity Associated Pathways.
Function
Wnt protein receptor. WNT3A, WNT3, WNT1 and to a lesser extent WNT2 are activated, but WNT4, WNT5A, WNT5B, WNT6, WNT7A, and WNT7B are not activated. The result of WNT7B activation is contradictory (similarity) with that of mice. The function in the standard Wnt/-catenin signaling pathway. The classic Wnt/ -catenin signaling pathway leads to the activation of messy proteins, the inhibition of GSK-3 kinase, the nuclear accumulation of -catenin, and the activation of Wnt target genes. A second signaling pathway involving PKC and calcium flux has been found in some family members, but it is not clear whether it represents a unique pathway or whether it can be integrated into the canonical pathway because of Wnt-mediated GSK-3 Kinase inactivation seems to require PKC. Both of these pathways seem to involve interaction with protein g. It may be involved in the formation of tissue morphology and/or the transduction of polarity information and cell-to-cell transmission in differentiated tissues (possibly).
Post-translational modifications
Ubiquitinated by ZNRF3, leading to its degradation by the proteasome.
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
18R8
Description
The antibody binds to human frizzled receptor and confirmed to inhibit Wnt signaling and/or inhibit tumor growth.
Antibody Indication
Cancer
