Book a Meeting

Anti-Fucosyl GM1 Antibody, Non-Fucosylated (7E4) (CAT#: BioBet-931ZP) Datasheet

Target
Fucosyl GM1
Isotype
IgG1
Description
Anti-Fucosyl GM1 Antibody, Non-Fucosylated (BioBet-931ZP) is a human monoclonal IgG1 antibody against Fucosyl GM1. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Cancer
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Fucosyl GM1 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
GM1
Full Name
Extended Type I glycosphingolipid
Background
Fucosyl-GM1 is a sphingolipid monosialoganglioside composed of a ceramide lipid component, which anchors the molecule in the cell membrane, and a carbohydrate component that is exposed at the cell surface.
Alternative Names
Fucosyl GM1; GM1
UniProt ID
Q9UK05
Cellular Localization
Golgi apparatus
Involvement in Disease
Diseases associated with FUT2 include Vitamin B12 Plasma Level Quantitative Trait Locus 1 and Bombay Phenotype.
Related Pathways
Its related pathways are Glycosphingolipid biosynthesis - lacto and neolacto series and Metabolism.
Function
Catalyzes the transfer of L-focuse, from a guanosine diphosphate-beta-L-focuse, to the terminal two O-galactose and N-linked glycan chains on the cell surface glycoproteins and glycolipids and the resulting antigenic determination Base regulation and other processes and information interaction include host interaction, cell surface expression and cell proliferation. Preferential concentration of gangliosides GA1 and GM1 in the sinus, cecum, colon and female reproductive organs (due to similarity). Fucosylated host glycoprotein or glycolipid mediates the interaction with intestinal microbes and affects its composition. A soluble precursor oligosaccharide fuco-alpha ((1,2)Galbeta-) is produced, called H antigen, which is a necessary substrate for the last step of the soluble ABO blood group antigen synthesis pathway.
Post-translational modifications
1.Glycosylation at Asn188, Asn282, and Asn308 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG1
Antibody Clone
7E4
Host
Human
Species Reactivity
Human
Description
The monoclonal antibody that specifically bind to Fucosyl-GM1 with high affinity are used for detecting Fucosyl-GM1, as well as treating various diseases, including cancer.
Antibody Indication
Cancer

Cancer

Related Products

Anti-Fucosyl GM1 Antibody, Non-Fucosylated (5B1) (CAT#: BioBet-932ZP)

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

  • *
  • *
  • *
USA

UK

Germany

ISO 9001 Certified - Creative Biolabs Quality Management System.