Anti-Frizzled Receptor Antibody, Highly Galactosylated (BioBet-GA-239ZP) (CAT#: BioBet-GA-239ZP) Datasheet

Frizzled Receptor

Vantictumab; 1345009-45-1; OMP-18R5; FZD1; frizzled family receptor 1; frizzled (Drosophila) homolog 1, frizzled 1, seven transmembrane spanning receptor, frizzled homolog 1 (Drosophila); frizzled-1; DKFZp564G072; frizzled; Drosophila; homolog of; 1; Wnt receptor

Plasma membrane

Its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and Association Between Physico-Chemical Features and Toxicity Associated Pathways.

Wnt protein receptor. WNT3A, WNT3, WNT1 and to a lesser extent WNT2 are activated, but WNT4, WNT5A, WNT5B, WNT6, WNT7A, and WNT7B are not activated. The result of WNT7B activation is contradictory (similarity) with the result of mice. The function in the standard Wnt/-catenin signaling pathway. The classic Wnt/ -catenin signaling pathway leads to the activation of messy proteins, the inhibition of GSK-3 kinase, the nuclear accumulation of -catenin, and the activation of Wnt target genes. A second signaling pathway involving PKC and calcium flux has been found in some family members, but it is not clear whether it represents a unique pathway or whether it can be integrated into the canonical pathway because of Wnt-mediated GSK-3 Kinase inactivation seems to require PKC. Both of these pathways seem to involve interaction with protein g. It may be involved in the formation of tissue morphology and/or the transduction of polarity information and cell-to-cell transmission in differentiated tissue (possibly).

Cell membrane; Multi-pass membrane protein.

Ubiquitinated by ZNRF3, leading to its degradation by the proteasome.

Protein Based Therapies
Monoclonal antibody (mAb)

IgG2, λ

BioBet-GA-239ZP

Human

Human

This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant human monoclonal antibody expressed in CHO binding to human Frizzled receptor. Vantictumab is a monoclonal antibody designed for the treatment of cancer.

Solid tumors

Solid tumors