Anti-FOLH1 Antibody, Non-Fucosylated (BioBet-236ZP) (CAT#: BioBet-236ZP) Datasheet

FOLH1

Folate Hydrolase 1

This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants encoding several different isoforms. [provided by RefSeq, Jul 2010]

FOLH1; folate hydrolase (prostate-specific membrane antigen) 1; FOLH; glutamate carboxypeptidase 2; GCP2; GCPII; glutamate carboxylase II;

Plasma membrane

Diseases associated with FOLH1 include Prostate Cancer and Canavan Disease.

Its related pathways are Circadian entrainment and One carbon pool by folate.

1.It has folate hydrolase and n-acetylation-chain acid dipeptidase (NAALADase) activities. Preference for tri--glutamate peptides. The absorption of folic acid in the small intestine in the brain regulates excitatory neurotransmission through the hydrolysis of the neuropeptide N-aceylaspartylglutamate (NAAG), thereby releasing glutamate. Participate in prostate tumor progression.2.It also exhibits dipeptidase-peptidase type IV activity. In vitro, cleaves Gly-Pro-AMC.

Cancer antibody; Metabolism antibody; Signaling Transduction antibody

The first two amino acids at the N-terminus of isoform PSMA' appear to be cleaved by limited proteolysis. The N-terminus is blocked. Ferroptosis MORE

Protein Based Therapies
Monoclonal antibody (mAb)

IgG1, κ

BioBet-236ZP

Human

Human

This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to Human PMSA. Capromab is a mouse monoclonal antibody which recognizes prostate specific membrane antigen (PSMA) from prostate cancer cells and normal prostate tissue.