Description
Anti-folate receptor 1 Antibody, Highly Galactosylated (BioBet-GA-238ZP) is a humanized IgG1, κ antibody against folate receptor 1 which contains with a high level of galactosylation.
Antibody Indication
Ovarian cancers
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced folate receptor 1 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
FOLR1
Full Name
Folate Receptor 1
Background
The protein encoded by this gene is a member of the folate receptor family. Members of this gene family bind folic acid and its reduced derivatives, and transport 5-methyltetrahydrofolate into cells. This gene product is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. Mutations in this gene have been associated with neurodegeneration due to cerebral folate transport deficiency. Due to the presence of two promoters, multiple transcription start sites, and alternative splicing, multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Oct 2009]
Alternative Names
Farletuzumab;896723-44-7;MORAb-003;LK26;MORAb-003;FOLR1;folate receptor 1 (adult);FOLR;folate receptor alpha;FR-alpha;KB cells FBP;folate binding protein;folate receptor, adult;adult folate-binding protein;ovarian tumor-associated antigen MOv18;FBP;
Gene ID
2348
UniProt ID
P15328
Cellular Localization
Endosome, Plasma membrane, Extracellular region or secreted
Genecards
3791
Involvement in Disease
Its related pathways are Transport to the Golgi and subsequent modification and Folate Metabolism.
Related Pathways
It binds to folic acid and reduced folic acid derivatives, and mediates 5-methyltetrahydrofolate and folic acid analogs into the cell interior. Under neutral pH conditions, it has a high affinity for folic acid and folic acid analogs. After receptor endocytosis, exposure to slightly acidic pH conditions will cause conformational changes, strongly reduce its affinity for folic acid, and mediate its release. It is necessary for normal embryo development and cell proliferation.
Field of research
The secreted form is derived from the membrane-bound form either by cleavage of the GPI anchor, or/and by proteolysis catalyzed by a metalloprotease.
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG1, κ
Antibody Clone
BioBet-GA-238ZP
Description
Recombinant monoclonal antibody to folate receptor 1. Farletuzumab (MORAb-003) is a monoclonal antibody which is being investigated for the treatment of ovarian cancer, It is targeted at FR-alpha which is overexpressed in some cancers such as ovarian cancer.
Antibody Indication
Ovarian cancers
