Anti-FMS-like tyrosine kinase-1 Antibody, Non-Fucosylated (BioBet-893ZP) (CAT#: BioBet-893ZP) Datasheet

FLT1

fms-related tyrosine kinase 1

This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.

FLT1; fms-related tyrosine kinase 1; FLT; FLT-1; VEGFR1; VEGFR-1; vascular endothelial growth factor receptor 1; fms-like tyrosine kinase 1; tyrosine-protein kinase FRT; tyrosine-protein kinase receptor FLT; vascular permeability factor receptor; fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)

Plasma membrane, Extracellular region or secreted, Endosome

Diseases associated with FLT1 include Pre-Eclampsia and Corneal Neovascularization.

Its related pathways are Transcriptional misregulation in cancer and Signaling by GPCR.

Tyrosine-protein kinase, as the cell surface receptor of VEGFA, VEGFB and PGF, plays an important role in embryonic blood vessel development, angiogenesis regulation, cell survival, cell migration, macrophage function, chemotaxis and cancer cell invasion. . It may play an important role as a negative regulator of embryonic angiogenesis by inhibiting the excessive proliferation of endothelial cells. It can promote the proliferation, survival and angiogenesis of skin cells in adulthood. Its function of promoting cell proliferation seems to be cell type specific. It can promote pgf-mediated proliferation of endothelial cells and certain types of cancer cells, but does not promote the proliferation of normal fibroblasts in vitro. It has a high affinity for VEGFA and relatively low protein kinase activity; it may act as a negative regulator of VEGFA signal, limiting the amount of free VEGFA and preventing it from binding to KDR. Similarly, isomers lacking a transmembrane domain, such as isomer 2, isomer 3, and isomer 4, may act as decoy receptors for VEGFA. KDR signal is regulated by forming heterodimer with KDR. Ligand binding leads to the activation of multiple signal cascades. Activation of PLCG leads to the production of cell signaling molecules diglyceride and inositol 1,4,5-trisphosphate and activation of protein kinase c-mediated phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leading to activation of phosphatidyl Inositol kinase and downstream signaling pathways. It mediates the activation of MAPK1/ERK2, MAPK3/ERK1 and map kinase signaling pathways, and the activation of AKT1 signaling pathways. Phosphorylation of SRC and YES1 may also phosphorylate CBL. Isoform 1 phosphorylates PLCG. Promote the phosphorylation of Ser-473 at AKT1. Promote the phosphorylation of PTK2/FAK1. Isoform 7 has a truncated kinase domain; it increases the phosphorylation of SRC at Tyr-418 in an unknown way and promotes tumor cell invasion.

Cancer antibody; Cell Biology and Cellular Response antibody; Metabolism antibody; Signaling Transduction antibody

N-glycosylated. Ubiquitinated after VEGFA-mediated autophosphorylation, leading to proteolytic degradation. Autophosphorylated on tyrosine residues upon ligand binding. Autophosphorylation occurs in trans, i.e. one subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit. Phosphorylation at Tyr-1169 is important for interaction with PLCG. Phosphorylation at Tyr-1213 is important for interaction with PIK3R1, PTPN11, GRB2, and PLCG. Phosphorylation at Tyr-1333 is important for endocytosis and for interaction with CBL, NCK1 and CRK. Is probably dephosphorylated by PTPRB.

Protein Based Therapies
Monoclonal antibody (mAb)

IgG

BioBet-893ZP

Humanized

Human

This is an anti-sFlt-1 receptor (sFlt-1) antibody used for treating a pregnancy related hypertensive disorder, such as pre-eclampsia and eclampsia.

Hypertensive Disorder

Hypertensive Disorder