Description
Anti-Ficolin-3 Antibody, Non-Fucosylated (BioBet-870ZP) is a human monoclonal IgG antibody against Ficolin-3. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Autoimmune Diseases
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Ficolin-3 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Full Name
ficolin (collagen/fibrinogen domain containing) 3
Background
Ficolins are a group of proteins which consist of a collagen-like domain and a fibrinogen-like domain. In human serum, there are two types of ficolins, both of which have lectin activity. The protein encoded by this gene is a thermolabile beta-2-macroglycoprotein found in all human serum and is a member of the ficolin/opsonin p35 lectin family. The protein, which was initially identified based on its reactivity with sera from patients with systemic lupus erythematosus, has been shown to have a calcium-independent lectin activity. The protein can activate the complement pathway in association with MASPs and sMAP, thereby aiding in host defense through the activation of the lectin pathway. Alternative splicing occurs at this locus and two variants, each encoding a distinct isoform, have been identified.
Alternative Names
FCN3; ficolin (collagen/fibrinogen domain containing) 3; FCNH; HAKA1; ficolin-3; H-ficolin; ficolin 3; collagen/fibrinogen domain-containing protein 3; collagen/fibrinogen domain-containing lectin 3 p35; ficolin (collagen/fibrinogen domain containing) 3 (Hakata antigen)
Cellular Localization
Extracellular region or secreted
Involvement in Disease
Diseases associated with FCN3 include Ficolin 3 Deficiency and Rheumatic Fever.
Related Pathways
Its related pathways are Innate Immune System and Creation of C4 and C2 activators.
Function
It may play a role in innate immunity by activating the lectin complement pathway. Calcium-dependent and glcnac-binding lectin. It has affinity with GalNAc, GlcNAc, D-focuse, as mono/oligosaccharides and lipopolysaccharides from Zebragrass and Minnesota.
Post-translational modifications
The N-terminus is blocked.
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Description
The novel antibody against Ficolin-3 inhibit complement activation, used in the treatment of conditions associated with inflammation, apoptosis, autoimmunity, coagulation, thrombotic or coagulopathic related diseases, as well as the use as biomarkers.
Antibody Indication
Autoimmune Diseases
