Anti-fibronectin extra domain-B Antibody, Highly Galactosylated (BioBet-GA-235ZP) (CAT#: BioBet-GA-235ZP) Datasheet

FN1

Fibronectin 1

This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. The encoded preproprotein is proteolytically processed to generate the mature protein. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants, at least one of which encodes an isoform that undergoes proteolytic processing. The full-length nature of some variants has not been determined. [provided by RefSeq, Jan 2016]

Radretumab;1253180-81-2;L19 I131 SIP;L19SIP;FN1;fibronectin 1;fibronectin;CIG;cold insoluble globulin;FINC;GFND2;LETS;migration stimulating factor;MSF;cold-insoluble globulin;migration-stimulating factor;FN;FNZ;ED-B;GFND;DKFZp686H0342;DKFZp686I1370;DKFZp6

Extracellular region or secreted

Its related pathways are Association Between Physico-Chemical Features and Toxicity Associated Pathways and Simplified Interaction Map Between LOXL4 and Oxidative Stress Pathway.

1.Fibronectin binds to the cell surface and various compounds, including collagen, fibrin, heparin, DNA, and actin. Fibronectin is involved in cell adhesion, cell movement, conditioning, wound healing and cell morphology maintenance. The matrix assembly process mediated by fibronectin fibroblasts participates in the compaction of osteoblasts, which is essential for osteoblast mineralization. Involved in the regulation of type I collagen deposition by osteoblasts 2.Anastellin binds to fibronectin and induces fiber formation. This fibronectin polymer, known as super fibronectin, exhibits enhanced adhesion properties. Both anastellin and superfibronectin inhibit tumor growth, angiogenesis and metastasis. Anastellin activates p38 MAPK and inhibits lysophospholipid signaling.

Sulfated. It is not known whether both or only one of Thr-2064 and Thr-2065 are/is glycosylated. Forms covalent cross-links mediated by a transglutaminase, such as F13A or TGM2, between a glutamine and the epsilon-amino group of a lysine residue, forming homopolymers and heteropolymers (e.g. fibrinogen-fibronectin, collagen-fibronectin heteropolymers). Phosphorylated by FAM20C in the extracellular medium. Proteolytic processing produces the C-terminal NC1 peptide, anastellin. Some lysine residues are oxidized to allysine by LOXL3, promoting fibronectin activation and matrix formation.

Protein Based Therapies
Monoclonal antibody (mAb)

[(scFv - heavy - kappa) - IGHE - CH4]2

BioBet-GA-235ZP

Human

Human

Recombinant monoclonal antibody to fibronectin extra domain-B. Radretumab is an antineoplastic. It binds to fibronectin extra domain-B.

Solid tumors

Solid tumors