Anti-Fibrin Gamma C domain Antibody, Non-Fucosylated (BioBet-890ZP) (CAT#: BioBet-890ZP) Datasheet

FGG

fibrinogen gamma chain

The protein encoded by this gene is the gamma component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia. Alternative splicing results in two transcript variants encoding different isoforms.

FGG; fibrinogen gamma chain; fibrinogen, gamma polypeptide

Extracellular region or secreted

Diseases associated with FGG include Afibrinogenemia, Congenital and Dysfibrinogenemia, Congenital.

Its related pathways are Activated TLR4 signalling and RET signaling.

Polymerizes with fibrinogen (FGA) and fibrinogen (FGB) to form an insoluble fibrin matrix. As one of the main components of blood clots, it plays an important role in hemostasis. In addition, it has the function of stabilizing damage and guiding cell migration in the early stage of wound repair. It was initially thought to be essential for platelet aggregation, which was based on in vitro anticoagulation studies. However, subsequent studies have shown that it is not necessary for the formation of blood clots in the body. Enhance the expression of SELP in activated platelets through itgb3-dependent pathways. The mother's fibrinogen is essential to a successful pregnancy. Fibrin deposition is also associated with infection, and it can prevent ifng-mediated bleeding. It is also possible to promote antibacterial immune responses through innate and T cell-mediated pathways.

Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers. Sulfation of C-terminal tyrosines increases affinity for thrombin.

Protein Based Therapies
Monoclonal antibody (mAb)

IgG

BioBet-890ZP

Mouse

Human

This is an antibody blockade or mutation of the fibrinogen γ-chain C-terminus is more effective in inhibiting murine arterial thrombus formation than complete absence of fibrinogen.

Multiple Sclerosis

Multiple Sclerosis