Anti-Fibrin Antibody, Non-Fucosylated (BioBet-891ZP) (CAT#: BioBet-891ZP) Datasheet

Fibrin

Fibrin

Fibrin (also called Factor Ia) is a fibrous, non-globular protein involved in the clotting of blood. It is formed by the action of the protease thrombin on fibrinogen which causes the latter to polymerize. The polymerized fibrin together with platelets forms a hemostatic plug or clot over a wound site.

Fibrin; Factor Ia

Extracellular region or secreted

Diseases associated with F13B include Factor Xiii, B Subunit, Deficiency Of and Factor Xiii Deficiency.

Its related pathways are Response to elevated platelet cytosolic Ca2+ and Androstenedione and testosterone biosynthesis and metabolism p.1.

The B chain of factor XIII is not catalytically active, but is thought to stabilize the A subunits and regulate the rate of transglutaminase formation by thrombin.

Cell Biology and Cellular Response antibody; Metabolism antibody

The alpha chain is normally not N-glycosylated (PubMed:23151259), even though glycosylation at Asn-686 was observed when a fragment of the protein was expressed in insect cells (PubMed:9689040). It is well known that heterologous expression of isolated domains can lead to adventitious protein modifications. Besides, glycosylation at Asn-686 is supported by large-scale glycoproteomics studies (PubMed:16335952 and PubMed:19159218), but the evidence is still quite tenuous. Most likely, Asn-686 is not glycosylated in the healthy human body, or only with low efficiency. O-glycosylated. Forms F13A-mediated cross-links between a glutamine and the epsilon-amino group of a lysine residue, forming fibronectin-fibrinogen heteropolymers. About one-third of the alpha chains in the molecules in blood were found to be phosphorylated. Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers. Phosphorylated by FAM20C in the extracellular medium.

Protein Based Therapies
Monoclonal antibody (mAb)

IgG

BioBet-891ZP

Mouse

Human

The Fibrin-specific antibody are used to immundiagnostic and immunotherapeutic applications.

Immune Disorders

Immune Disorders