Anti-FGF2 Antibody, Non-Fucosylated (HuGAL-F2) (CAT#: BioBet-882ZP) Datasheet

FGF2

fibroblast growth factor 2 (basic)

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF.

FGF2; fibroblast growth factor 2 (basic); BFGF; FGFB; FGF-2; HBGF-2; fibroblast growth factor 2; prostatropin; heparin-binding growth factor 2; basic fibroblast growth factor bFGF

Extracellular region or secreted, Nucleus

Diseases associated with FGF2 include Corneal Neovascularization and Chronic Ulcer Of Skin.

Its related pathways are RET signaling and Signaling by FGFR2 in disease.

As a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. It also serves as an integrin ligand required by the FGF2 signaling pathway. Combine integrin ITGAV: ITGB3. It plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. As an effective mitogen in vitro. Can induce angiogenesis. Mediates the phosphorylation of ERK1/2, thereby promoting the differentiation of retinal lens fibers.

Cancer antibody; Controls and Markers antibody; Developmental Biology antibody; Signaling Transduction antibody

Following secretion this protein is inactivated by cleavage into a N-terminal fragment and a C-terminal fragment. The processing is effected by proprotein convertases. O-glycosylated by GALT3. Glycosylation is necessary for secretion; it blocks processing by proprotein convertases when the O-glycan is alpha 2,6-sialylated. Competition between proprotein convertase cleavage and block of cleavage by O-glycosylation determines the level of secreted active FGF23.

Protein Based Therapies
Monoclonal antibody (mAb)

IgG

HuGAL-F2

Humanized

Human

HuGAL-F2 is a humanized monoclonal antibody bings to Fibroblast Growth Factor 2, effectively inhibits the growth of hepatocellular carcinoma xenografts.

Cancer

Cancer