Anti-Fc-gamma-RIIIA Antibody, Non-Fucosylated (BioBet-867ZP) (CAT#: BioBet-867ZP) Datasheet

FCGR3A

Fc fragment of IgG, low affinity IIIa, receptor (CD16a)

This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

FCGR3A; Fc fragment of IgG, low affinity IIIa, receptor (CD16a); CD16; FCG3; CD16A; FCGR3; IGFR3; IMD20; FCR-10; FCRIII; FCGRIII; FCRIIIA; low affinity immunoglobulin gamma Fc region receptor III-A; FcgammaRIIIA; CD16a antigen; fc-gamma RIII; Fc-gamma RIIIa; Fc-gamma RIII-alpha; igG Fc receptor III-2; Fc gamma receptor III-A; Fc-gamma receptor IIIb (CD16); neutrophil-specific antigen NA; Fc-gamma receptor III-2 (CD 16); immunoglobulin G Fc receptor III; Fc fragment of IgG, low affinity III, receptor for (CD16)

Plasma membrane, Extracellular region or secreted

Diseases associated with FCGR3A include Immunodeficiency 20 and Herpes Zoster.

Its related pathways are Tuberculosis and Immune response Role of DAP12 receptors in NK cells.

The receptor is the Fc region of IgG. Combine complex or aggregated IgG and monomeric IgG. Mediates antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent reactions, such as phagocytosis.

Developmental Biology antibody; Immune System antibody; General Lymphocyte Marker Study antibody; Natural killer cells antibody

Glycosylated. Contains high mannose- and complex-type oligosaccharides. Glycosylation at Asn-180 is mandatory for high affinity binding to the Fc and for discrimination between fucosylated and afucosylated IgG glycoforms. The soluble form is produced by a proteolytic cleavage.

Protein Based Therapies
Monoclonal antibody (mAb)

IgG

BioBet-867ZP

Humanized

Human

The humanized anti-cd16A antibody are used for the treatment of immune disorders such as idiopathic thrombocytopenic purpura and autoimme hemolytic anemia.

Immune Disorders

Immune Disorders