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Creative Biolabs - ADCC+ Antibody

Anti-Fc-gamma-RIIB Antibody, Non-Fucosylated (BioBet-866ZP) (CAT#: BioBet-866ZP) Datasheet

Target
Fc-gamma-RIIB (CD32b)
Isotype
IgG
Description
Anti-Fc-gamma-RIIB Antibody, Non-Fucosylated (BioBet-866ZP) is a human monoclonal IgG antibody against Fc-gamma-RIIB (CD32b). This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Autoimmune Diseases
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Fc-gamma-RIIB (CD32b) antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
FCGR2B
Full Name
Fc fragment of IgG, low affinity IIb, receptor (CD32)
Background
The protein encoded by this gene is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms have been found for this gene.
Alternative Names
FCGR2B; Fc fragment of IgG, low affinity IIb, receptor (CD32); CD32; FCG2; CD32B; FCGR2; IGFR2; low affinity immunoglobulin gamma Fc region receptor II-b; CDw32; fcRII-b; Fc gamma RIIb; fc-gamma-RIIb; fc-gamma RII-b; igG Fc receptor II-b; Fc fragment of IgG, low affinity II, receptor for (CD32); Fc fragment of IgG, low affinity IIb, receptor for (CD32)
Gene ID
2213
Cellular Localization
Plasma membrane
Involvement in Disease
Diseases associated with FCGR2B include Systemic Lupus Erythematosus and Malaria.
Related Pathways
Its related pathways are B cell receptor signaling pathway (KEGG) and Tuberculosis.
Function
Complex or aggregated immunoglobulin Fc region receptor. Low affinity receptor. Participate in a variety of effects and regulatory functions, such as the phagocytosis of immune complexes and the regulation of b-cell antibody production. Binding to this receptor leads to down-regulation of cell activation triggered by antigen receptors on b cells (BCR), t cells (TCR), or other Fc receptors. Subtype IIB1 cannot mediate endocytosis or phagocytosis. Subtype IIB2 does not trigger phagocytosis.
Field of research
Developmental Biology antibody; Immune System antibody
Post-translational modifications
Phosphorylated by the SRC-type Tyr-kinases LYN and BLK.
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
BioBet-866ZP
Host
Human
Species Reactivity
Human
Description
SM201 is an anti-hFcγRIIB antibody not interfering with ligand binding that mediates immune complex dependent inhibition of B cells, it can be used for the treatment of antibody-mediated autoimmune diseases.
Antibody Indication
Autoimmune Diseases

Autoimmune Diseases

All products and services are for Research Use Only. Do Not use in humans.

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