Description
Anti-Fc-gamma-RIIA Antibody, Non-Fucosylated (BioBet-865ZP) is a human monoclonal IgG antibody against Fc-gamma-RIIA. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Autoimmune Disease
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Fc-gamma-RIIA antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
FCGR2A
Full Name
Fc fragment of IgG, low affinity IIa, receptor (CD32)
Background
This gene encodes one member of a family of immunoglobulin Fc receptor genes found on the surface of many immune response cells. The protein encoded by this gene is a cell surface receptor found on phagocytic cells such as macrophages and neutrophils, and is involved in the process of phagocytosis and clearing of immune complexes. Alternative splicing results in multiple transcript variants.
Alternative Names
FCGR2A; Fc fragment of IgG, low affinity IIa, receptor (CD32); CD32; FCG2; FcGR; CD32A; CDw32; FCGR2; IGFR2; FCGR2A1; low affinity immunoglobulin gamma Fc region receptor II-a; fcRII-a; fc-gamma-RIIa; fc-gamma RII-a; igG Fc receptor II-a; Immunoglobulin G Fc receptor II
Gene ID
2212
Cellular Localization
Plasma membrane
Involvement in Disease
Diseases associated with FCGR2A include Cystic Fibrosis and Systemic Lupus Erythematosus.
Related Pathways
Its related pathways are Tuberculosis and Pathogenic Escherichia coli infection.
Function
Binds to the Fc region of immunoglobulins. Low affinity receptor. By binding to IgG, it initiates the cell's response to pathogens and soluble antigens. Promote the phagocytosis of opsonized antigens.
Field of research
Developmental Biology antibody; Immune System antibody
Post-translational modifications
Phosphorylated by SRC-type Tyr-kinases such as LYN, BLK, FYN, HCK and SYK.
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
BioBet-865ZP
Description
This is an anti-CD32 antibody used in treating an autoimmune disease.
Antibody Indication
Autoimmune Disease
