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Anti-Fc-epsilon-Receptor I Antibody, Non-Fucosylated (CAT#: BioBet-863ZP) Datasheet

Target
Fc-epsilon-Receptor I
Isotype
IgG
Description
Anti-Fc-epsilon-Receptor I Antibody, Non-Fucosylated (BioBet-863ZP) is a human monoclonal IgG antibody against Fc-epsilon-Receptor I. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Allergic Disorders
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Fc-epsilon-Receptor I antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
FCER1A
Full Name
Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
Background
The immunoglobulin epsilon receptor (IgE receptor) is the initiator of the allergic response. When two or more high-affinity IgE receptors are brought together by allergen-bound IgE molecules, mediators such as histamine that are responsible for allergy symptoms are released. This receptor is comprised of an alpha subunit, a beta subunit, and two gamma subunits. The protein encoded by this gene represents the alpha subunit.
Alternative Names
FCER1A; Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide; FCE1A; FcERI; high affinity immunoglobulin epsilon receptor subunit alpha; Fc-epsilon RI-alpha; Fc epsilon RI alpha-chain; igE Fc receptor subunit alpha; Fc IgE receptor, alpha polypeptide; high affinity immunoglobulin epsilon receptor alpha-subunit; immunoglobulin E receptor, high-affinity, of mast cells, alpha polypeptide
Gene ID
2205
Cellular Localization
Plasma membrane
Involvement in Disease
Diseases associated with FCER1A include Dermatographia and Physical Urticaria.
Related Pathways
Its related pathways are Immune response Fc epsilon RI pathway and Sphingolipid signaling pathway.
Function
Binds to the Fc region of immunoglobulin epsilon. High affinity receptor. Responsible for triggering allergic reactions. The binding of the allergen to the receptor-bound IgE leads to cell activation and the release of mediators (such as histamine), leading to allergic manifestations. The same receptor also induces the secretion of important lymphokines.
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
BioBet-863ZP
Host
Human
Species Reactivity
Human
Description
This is an anti-FceRI antibody for use in treating an autoimmune disease.
Antibody Indication
Allergic Disorders

Allergic Disorders

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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