Anti-Fc alpha receptor Antibody, Non-Fucosylated (BioBet-862ZP) (CAT#: BioBet-862ZP) Datasheet

FCAR

Fc fragment of IgA, receptor for

This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene.

FCAR; Fc fragment of IgA, receptor for; CD89; FcalphaRI; immunoglobulin alpha Fc receptor; Fc alpha receptor

Plasma membrane, Extracellular region or secreted

Diseases associated with FCAR include Iga Nephropathy 1 and Iga Glomerulonephritis.

Its related pathways are Innate Immune System and Phagosome.

Binds to the Fc region of immunoglobulins alpha. Mediates several functions including cytokine production.

1.Glycosylation at Asn141, Asn65, Asn79, Asn177, and Asn186 2.Modification sites at PhosphoSitePlus

Protein Based Therapies
Monoclonal antibody (mAb)

IgG

HuMAb 8D2

Human

Human

The human monoclonal antibody which bind specifically to Fc alpha receptor (CD89) are useful for targeting human effector cells (e. g. macrophages) against a target cell (e. g. a cancer cell, an infectious agent, etc. ).

Cancer

Cancer